Investigation of the transcriptional host response to SARS-CoV-2 identifies an imbalance in the host response which drives the development of COVID-19

Coronaviruses are a group of single-stranded RNA viruses with a wide range of hosts1. Recently, three highly pathogenic human coronaviruses have emerged from animal to human transmission, they are SARS-CoV-1, MERS-CoV, and most recently, SARS-CoV-22.